The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP1LC3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP1LC3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP1LC3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:87,264,671–87,265,109 | 127.4 kb | Distal (>10kb) Multiome | 88 | |
| chr16:87,278,468–87,279,093 | 113.5 kb | Distal (>10kb) Multiome | 284 | |
| chr16:87,305,529–87,306,047 | 86.5 kb | Distal (>10kb) Multiome | 282 | |
| chr16:87,316,905–87,317,759 | 74.9 kb | Distal (>10kb) Multiome | 945 | |
| chr16:87,382,568–87,384,888 | 8.4 kb | Proximal (<10kb) Multiome | 1122 | |
| chr16:87,388,081–87,388,660 | 3.9 kb | Proximal (<10kb) Multiome | 794 | |
| chr16:87,391,244–87,393,452 | 152 bp | At TSS Multiome | 1038 | |
| chr16:87,492,670–87,493,484 | 100.7 kb | Distal (>10kb) Multiome | 652 | |
| chr16:87,601,726–87,602,537 | 210.0 kb | Distal (>10kb) Multiome | 217 |
Genomic view of the MAP1LC3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.