This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MANBA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MANBA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MANBA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:102,493,204–102,493,987 | 267.5 kb | Distal (>10kb) Multiome | 194 | |
| chr4:102,500,438–102,502,654 | 259.3 kb | Distal (>10kb) Multiome | 906 | |
| chr4:102,759,924–102,761,752 | 41 bp | At TSS Multiome | 907 | |
| chr4:102,826,418–102,828,875 | 67.1 kb | Distal (>10kb) Multiome | 1216 | |
| chr4:102,868,279–102,869,865 | 108.1 kb | Distal (>10kb) Multiome | 1045 | |
| chr4:103,018,881–103,020,188 | 258.7 kb | Distal (>10kb) Multiome | 882 |
Genomic view of the MANBA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.