Alpha-mannosidases function at different stages of N-glycan maturation in mammalian cells. See MAN2A1 (MIM 154582) for general information.[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for MAN1A2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAN1A2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAN1A2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:117,121,317–117,122,916 | 245.5 kb | Distal (>10kb) Multiome | 747 | |
| chr1:117,268,677–117,269,503 | 98.2 kb | Distal (>10kb) Multiome | 284 | |
| chr1:117,346,297–117,347,531 | 20.7 kb | Distal (>10kb) Multiome | 215 | |
| chr1:117,358,134–117,358,512 | 8.9 kb | Proximal (<10kb) | 28 | |
| chr1:117,366,239–117,368,025 | 295 bp | At TSS Multiome | 887 | |
| chr1:117,605,087–117,607,365 | 238.5 kb | Distal (>10kb) Multiome | 787 |
Genomic view of the MAN1A2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.