Transcription factors with Perturb-seq knockdown data for MAMDC2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAMDC2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAMDC2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:69,820,343–69,821,096 | 293.1 kb | Distal (>10kb) Multiome | 239 | |
| chr9:69,823,108–69,824,042 | 290.2 kb | Distal (>10kb) Multiome | 59 | |
| chr9:69,986,283–69,987,113 | 127.2 kb | Distal (>10kb) Multiome HiCAR | 65 | |
| chr9:70,043,398–70,045,147 | 69.0 kb | Distal (>10kb) Multiome | 310 | |
| chr9:70,110,542–70,111,264 | 2.6 kb | Proximal (<10kb) | 179 | |
| chr9:70,111,583–70,112,194 | 1.7 kb | Proximal (<10kb) | 92 | |
| chr9:70,113,500–70,113,727 | 132 bp | At TSS | 81 | |
| chr9:70,120,525–70,121,174 | 6.7 kb | Proximal (<10kb) | 121 | |
| chr9:70,256,089–70,256,627 | 142.5 kb | Distal (>10kb) Multiome | 140 | |
| chr9:70,258,134–70,259,705 | 145.0 kb | Distal (>10kb) Multiome | 919 |
Genomic view of the MAMDC2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.