This gene encodes a ubiquitously expressed magnesium cation transporter protein that localizes to the cell membrane. This protein also associates with N-oligosaccharyl transferase and therefore may have a role in N-glycosylation. Mutations in this gene cause a form of X-linked intellectual disability (XLID). This gene may have multiple in-frame translation initiation sites, one of which would encode a shorter protein with an N-terminus containing a signal peptide at amino acids 1-29. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for MAGT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:77,785,454–77,786,614 | 109.3 kb | Distal (>10kb) Multiome | 501 | |
| chrX:77,894,933–77,895,826 | 95 bp | At TSS Multiome | 543 | |
| chrX:77,899,137–77,899,809 | 4.0 kb | Proximal (<10kb) Multiome | 504 | |
| chrX:77,910,405–77,911,140 | 15.2 kb | Distal (>10kb) Multiome | 574 | |
| chrX:78,103,641–78,105,079 | 208.6 kb | Distal (>10kb) Multiome | 867 | |
| chrX:78,139,006–78,140,056 | 244.2 kb | Distal (>10kb) Multiome | 593 |
Genomic view of the MAGT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.