This gene belongs to the non-CT (non cancer/testis) subgroup of the melanoma-associated antigen (MAGE) superfamily. The encoded protein is likely associated with apoptosis, cell cycle arrest, growth inhibition or cell differentiation. The protein may be involved in the atRA (all-trans retinoic acid) signaling through the STAT1-alpha (signal transducer and activator of transcription 1-alpha) pathway. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for MAGEH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAGEH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAGEH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:54,921,216–54,922,087 | 530.3 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chrX:55,120,460–55,121,511 | 331.1 kb | Distal (>10kb) Multiome HiCAR | 226 | |
| chrX:55,152,693–55,153,258 | 299.2 kb | Distal (>10kb) Multiome HiCAR | 44 | |
| chrX:55,160,695–55,161,885 | 291.0 kb | Distal (>10kb) Multiome HiCAR | 679 | |
| chrX:55,451,759–55,452,541 | at TSS | At TSS | 345 | |
| chrX:55,488,316–55,490,325 | 37.8 kb | Distal (>10kb) Multiome HiCAR | 373 | |
| chrX:55,717,452–55,718,482 | 265.6 kb | Distal (>10kb) Multiome HiCAR | 579 |
Genomic view of the MAGEH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.