This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for MAEA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAEA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAEA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:1,002,360–1,003,561 | 286.7 kb | Distal (>10kb) Multiome | 176 | |
| chr4:1,008,768–1,012,870 | 278.4 kb | Distal (>10kb) Multiome | 793 | |
| chr4:1,113,486–1,113,937 | 176.2 kb | Distal (>10kb) Multiome | 183 | |
| chr4:1,167,206–1,167,987 | 122.3 kb | Distal (>10kb) Multiome | 553 | |
| chr4:1,247,634–1,250,121 | 40.9 kb | Distal (>10kb) Multiome | 835 | |
| chr4:1,286,239–1,286,420 | 3.5 kb | Proximal (<10kb) | 58 | |
| chr4:1,289,220–1,290,349 | 90 bp | At TSS Multiome | 769 | |
| chr4:1,309,299–1,309,921 | 19.7 kb | Distal (>10kb) Multiome | 461 | |
| chr4:1,345,929–1,347,890 | 57.2 kb | Distal (>10kb) Multiome | 864 | |
| chr4:1,512,763–1,513,500 | 223.4 kb | Distal (>10kb) Multiome | 317 | |
| chr4:1,578,390–1,579,916 | 289.4 kb | Distal (>10kb) Multiome | 472 | |
| chr4:1,580,022–1,580,836 | 290.8 kb | Distal (>10kb) Multiome | 412 |
Genomic view of the MAEA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.