The protein encoded by this gene was identified as a binding protein of the MAD2 mitotic arrest deficient-like 1 (MAD2/MAD2L1). MAD2 is a key component of the spindle checkpoint that delays the onset of anaphase until all the kinetochores are attached to the spindle. This protein may interact with the spindle checkpoint and coordinate cell cycle events in late mitosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAD2L1BP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAD2L1BP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAD2L1BP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:43,368,714–43,370,143 | 266.2 kb | Distal (>10kb) Multiome | 909 | |
| chr6:43,426,936–43,428,340 | 208.2 kb | Distal (>10kb) Multiome | 919 | |
| chr6:43,454,362–43,454,991 | 181.1 kb | Distal (>10kb) Multiome | 686 | |
| chr6:43,477,347–43,478,043 | 158.3 kb | Distal (>10kb) Multiome | 747 | |
| chr6:43,506,605–43,507,204 | 128.9 kb | Distal (>10kb) Multiome | 474 | |
| chr6:43,509,337–43,511,016 | 125.5 kb | Distal (>10kb) Multiome | 734 | |
| chr6:43,516,463–43,517,515 | 118.9 kb | Distal (>10kb) Multiome | 904 | |
| chr6:43,575,269–43,576,483 | 59.8 kb | Distal (>10kb) Multiome | 1044 | |
| chr6:43,625,568–43,626,341 | 9.5 kb | Proximal (<10kb) | 90 | |
| chr6:43,628,488–43,630,447 | 5.7 kb | Proximal (<10kb) Multiome | 1157 | |
| chr6:43,635,496–43,636,104 | 46 bp | At TSS Multiome | 941 | |
| chr6:43,644,712–43,645,902 | 9.5 kb | Proximal (<10kb) Multiome | 255 | |
| chr6:43,667,273–43,667,900 | 31.5 kb | Distal (>10kb) Multiome | 625 | |
| chr6:43,667,997–43,668,873 | 32.6 kb | Distal (>10kb) Multiome | 664 | |
| chr6:43,695,239–43,695,940 | 59.9 kb | Distal (>10kb) Multiome | 207 | |
| chr6:43,702,335–43,703,403 | 67.1 kb | Distal (>10kb) Multiome | 713 | |
| chr6:43,706,840–43,708,370 | 72.1 kb | Distal (>10kb) Multiome | 307 | |
| chr6:43,739,421–43,740,065 | 103.9 kb | Distal (>10kb) Multiome | 175 | |
| chr6:43,769,188–43,772,162 | 134.1 kb | Distal (>10kb) Multiome HiCAR | 1112 | |
| chr6:43,774,651–43,775,250 | 139.1 kb | Distal (>10kb) Multiome | 440 | |
| chr6:43,926,273–43,928,465 | 291.4 kb | Distal (>10kb) Multiome | 1000 |
Genomic view of the MAD2L1BP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.