MAD1L1 is a component of the mitotic spindle-assembly checkpoint that prevents the onset of anaphase until all chromosome are properly aligned at the metaphase plate. MAD1L1 functions as a homodimer and interacts with MAD2L1. MAD1L1 may play a role in cell cycle control and tumor suppression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Transcription factors with Perturb-seq knockdown data for MAD1L1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAD1L1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAD1L1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:1,458,555–1,460,310 | 773.3 kb | Distal (>10kb) Multiome HiCAR | 677 | |
| chr7:1,569,754–1,570,643 | 662.8 kb | Distal (>10kb) Multiome HiCAR | 876 | |
| chr7:2,232,261–2,233,424 | 51 bp | At TSS Multiome | 809 | |
| chr7:2,241,746–2,242,506 | 9.2 kb | Proximal (<10kb) Multiome | 794 | |
| chr7:2,313,875–2,314,819 | 81.6 kb | Distal (>10kb) Multiome HiCAR | 684 | |
| chr7:2,353,760–2,355,437 | 121.7 kb | Distal (>10kb) Multiome HiCAR | 1060 | |
| chr7:2,403,048–2,404,583 | 170.6 kb | Distal (>10kb) Multiome | 775 | |
| chr7:2,451,319–2,452,043 | 218.6 kb | Distal (>10kb) Multiome | 660 | |
| chr7:2,518,679–2,520,557 | 286.8 kb | Distal (>10kb) Multiome | 567 |
Genomic view of the MAD1L1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.