The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]
Transcription factors with Perturb-seq knockdown data for MACROD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MACROD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MACROD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:13,784,410–13,785,713 | 210.5 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:13,849,862–13,851,076 | 145.0 kb | Distal (>10kb) Multiome | 199 | |
| chr20:13,873,896–13,875,288 | 120.8 kb | Distal (>10kb) Multiome | 154 | |
| chr20:13,990,548–13,990,770 | 4.7 kb | Proximal (<10kb) | 43 | |
| chr20:13,994,818–13,996,684 | 123 bp | At TSS Multiome | 614 | |
| chr20:14,219,764–14,220,888 | 224.8 kb | Distal (>10kb) Multiome | 258 |
Genomic view of the MACROD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.