Predicted to enable microtubule binding activity. Involved in neuronal signal transduction. Located in rough endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MACO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MACO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MACO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,232,067–25,232,905 | 198.4 kb | Distal (>10kb) Multiome | 757 | |
| chr1:25,233,146–25,233,599 | 197.6 kb | Distal (>10kb) Multiome | 493 | |
| chr1:25,239,634–25,240,475 | 191.0 kb | Distal (>10kb) Multiome | 897 | |
| chr1:25,246,452–25,248,229 | 183.3 kb | Distal (>10kb) Multiome | 1054 | |
| chr1:25,338,116–25,338,949 | 92.5 kb | Distal (>10kb) Multiome | 803 | |
| chr1:25,429,935–25,431,604 | 695 bp | At TSS Multiome | 845 | |
| chr1:25,543,218–25,544,436 | 112.7 kb | Distal (>10kb) Multiome | 569 | |
| chr1:25,615,967–25,618,316 | 185.6 kb | Distal (>10kb) Multiome | 585 | |
| chr1:25,707,237–25,707,853 | 276.4 kb | Distal (>10kb) Multiome | 136 |
Genomic view of the MACO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.