MACC1 is a key regulator of the hepatocyte growth factor (HGF; MIM 142409)-HGF receptor (HGFR, or MET; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009]
Transcription factors with Perturb-seq knockdown data for MACC1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MACC1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MACC1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:20,053,213–20,053,692 | 163.8 kb | Distal (>10kb) Multiome | 21 | |
| chr7:20,120,210–20,122,603 | 96.5 kb | Distal (>10kb) Multiome | 276 | |
| chr7:20,125,703–20,126,837 | 91.1 kb | Distal (>10kb) Multiome | 167 | |
| chr7:20,214,924–20,215,519 | 1.9 kb | Proximal (<10kb) | 161 | |
| chr7:20,217,098–20,217,914 | 128 bp | At TSS Multiome | 460 | |
| chr7:20,218,398–20,218,569 | 1.0 kb | Proximal (<10kb) | 46 | |
| chr7:20,219,096–20,220,603 | 1.7 kb | Proximal (<10kb) | 899 | |
| chr7:20,226,067–20,226,279 | 8.7 kb | Proximal (<10kb) | 2 | |
| chr7:20,329,378–20,332,363 | 112.4 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the MACC1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.