The protein encoded by this gene belongs to the leucine zipper tumor suppressor family of proteins, which function in transcription regulation and cell cycle control. This family member can repress beta-catenin-mediated transcriptional activation and is a negative regulator of the Wnt signaling pathway. It negatively regulates microtubule severing at centrosomes, and is necessary for central spindle formation and cytokinesis completion. It is implicated in cancer, where it may inhibit cell proliferation and decrease susceptibility to tumor development. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for LZTS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LZTS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LZTS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:100,715,555–100,715,963 | 281.2 kb | Distal (>10kb) Multiome | 117 | |
| chr10:100,729,074–100,730,178 | 267.6 kb | Distal (>10kb) Multiome | 304 | |
| chr10:100,739,174–100,740,373 | 257.3 kb | Distal (>10kb) Multiome | 205 | |
| chr10:100,744,447–100,746,357 | 251.6 kb | Distal (>10kb) Multiome | 379 | |
| chr10:100,760,518–100,761,080 | 236.2 kb | Distal (>10kb) Multiome | 105 | |
| chr10:100,787,902–100,788,519 | 208.9 kb | Distal (>10kb) Multiome | 52 | |
| chr10:100,826,838–100,828,148 | 169.1 kb | Distal (>10kb) Multiome | 327 | |
| chr10:100,912,455–100,913,519 | 84.2 kb | Distal (>10kb) Multiome | 906 | |
| chr10:100,968,950–100,970,567 | 27.7 kb | Distal (>10kb) Multiome | 681 | |
| chr10:100,987,003–100,987,794 | 9.6 kb | Proximal (<10kb) Multiome | 786 | |
| chr10:100,994,403–100,994,731 | 2.3 kb | Proximal (<10kb) | 101 | |
| chr10:100,996,424–100,998,696 | 48 bp | At TSS Multiome | 945 | |
| chr10:100,998,810–101,000,165 | 2.5 kb | Proximal (<10kb) Multiome | 845 | |
| chr10:101,018,377–101,019,461 | 22.1 kb | Distal (>10kb) Multiome | 654 | |
| chr10:101,030,588–101,032,521 | 34.1 kb | Distal (>10kb) Multiome | 613 | |
| chr10:101,042,527–101,043,387 | 45.9 kb | Distal (>10kb) Multiome | 655 | |
| chr10:101,048,051–101,048,547 | 51.2 kb | Distal (>10kb) Multiome | 87 | |
| chr10:101,049,966–101,050,753 | 53.3 kb | Distal (>10kb) Multiome | 412 | |
| chr10:101,060,073–101,063,211 | 65.7 kb | Distal (>10kb) Multiome | 1124 | |
| chr10:101,066,181–101,066,983 | 69.4 kb | Distal (>10kb) Multiome | 734 | |
| chr10:101,067,105–101,068,123 | 70.8 kb | Distal (>10kb) Multiome | 643 | |
| chr10:101,095,368–101,096,269 | 98.7 kb | Distal (>10kb) Multiome | 326 | |
| chr10:101,131,094–101,132,387 | 134.3 kb | Distal (>10kb) Multiome | 289 | |
| chr10:101,139,407–101,140,520 | 142.7 kb | Distal (>10kb) Multiome | 158 | |
| chr10:101,161,678–101,162,270 | 164.8 kb | Distal (>10kb) Multiome | 336 | |
| chr10:101,214,601–101,215,378 | 217.9 kb | Distal (>10kb) Multiome | 302 | |
| chr10:101,217,392–101,218,117 | 220.6 kb | Distal (>10kb) Multiome | 203 | |
| chr10:101,236,527–101,237,332 | 239.9 kb | Distal (>10kb) Multiome | 123 | |
| chr10:101,282,747–101,283,297 | 286.0 kb | Distal (>10kb) Multiome | 74 | |
| chr10:101,285,534–101,286,046 | 288.8 kb | Distal (>10kb) Multiome | 150 | |
| chr10:101,288,327–101,289,007 | 291.6 kb | Distal (>10kb) Multiome | 96 | |
| chr10:101,291,317–101,293,346 | 294.7 kb | Distal (>10kb) Multiome | 433 |
Genomic view of the LZTS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.