This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LZTR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LZTR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LZTR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:20,702,218–20,703,674 | 279.3 kb | Distal (>10kb) Multiome | 438 | |
| chr22:20,857,959–20,859,512 | 123.6 kb | Distal (>10kb) Multiome | 901 | |
| chr22:20,885,370–20,886,088 | 96.5 kb | Distal (>10kb) Multiome | 749 | |
| chr22:20,916,779–20,918,119 | 65.1 kb | Distal (>10kb) Multiome | 985 | |
| chr22:20,957,739–20,958,321 | 24.5 kb | Distal (>10kb) Multiome | 346 | |
| chr22:20,979,087–20,980,257 | 2.8 kb | Proximal (<10kb) Multiome | 435 | |
| chr22:20,981,807–20,982,763 | 198 bp | At TSS Multiome | 1020 | |
| chr22:21,001,335–21,002,797 | 19.7 kb | Distal (>10kb) Multiome | 1021 | |
| chr22:21,013,880–21,015,021 | 32.0 kb | Distal (>10kb) Multiome | 661 | |
| chr22:21,045,516–21,046,316 | 63.5 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the LZTR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.