Predicted to enable beta-catenin binding activity. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LZIC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LZIC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LZIC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:9,651,631–9,652,549 | 291.3 kb | Distal (>10kb) Multiome | 373 | |
| chr1:9,687,158–9,688,089 | 255.8 kb | Distal (>10kb) Multiome | 575 | |
| chr1:9,688,950–9,690,301 | 253.8 kb | Distal (>10kb) Multiome | 585 | |
| chr1:9,823,213–9,824,739 | 119.3 kb | Distal (>10kb) Multiome | 652 | |
| chr1:9,874,956–9,875,558 | 68.3 kb | Distal (>10kb) Multiome HiCAR | 397 | |
| chr1:9,909,556–9,911,240 | 32.9 kb | Distal (>10kb) Multiome | 791 | |
| chr1:9,942,472–9,942,640 | 750 bp | At TSS | 239 | |
| chr1:9,942,849–9,943,619 | 73 bp | At TSS Multiome | 1015 | |
| chr1:9,950,420–9,950,631 | 7.0 kb | Proximal (<10kb) | 422 | |
| chr1:10,032,377–10,033,814 | 89.5 kb | Distal (>10kb) Multiome | 891 | |
| chr1:10,209,800–10,211,585 | 267.0 kb | Distal (>10kb) Multiome | 934 |
Genomic view of the LZIC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.