Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LYRM9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LYRM9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LYRM9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:27,892,882–27,893,663 | 53 bp | At TSS Multiome | 607 | |
| chr17:27,915,662–27,916,230 | 22.5 kb | Distal (>10kb) Multiome | 185 | |
| chr17:27,939,884–27,941,043 | 46.9 kb | Distal (>10kb) Multiome | 80 | |
| chr17:27,982,605–27,983,118 | 89.5 kb | Distal (>10kb) Multiome | 124 | |
| chr17:28,040,846–28,042,232 | 148.1 kb | Distal (>10kb) Multiome | 682 | |
| chr17:28,227,184–28,228,835 | 334.3 kb | Distal (>10kb) Multiome HiCAR | 426 | |
| chr17:28,251,169–28,251,939 | 358.2 kb | Distal (>10kb) Multiome HiCAR | 480 |
Genomic view of the LYRM9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.