Predicted to enable signaling receptor activity. Predicted to be involved in immune response and inflammatory response. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LY75. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LY75 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LY75, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:159,614,971–159,616,729 | 289.2 kb | Distal (>10kb) Multiome | 950 | |
| chr2:159,711,895–159,713,118 | 192.4 kb | Distal (>10kb) Multiome | 1191 | |
| chr2:159,797,654–159,798,386 | 106.7 kb | Distal (>10kb) Multiome | 794 | |
| chr2:159,903,833–159,905,297 | 21 bp | At TSS Multiome | 416 | |
| chr2:159,921,615–159,922,304 | 17.2 kb | Distal (>10kb) Multiome | 433 | |
| chr2:160,061,841–160,063,521 | 157.9 kb | Distal (>10kb) Multiome | 353 |
Genomic view of the LY75 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.