The LUC7L gene may represent a mammalian heterochromatic gene, encoding a putative RNA-binding protein similar to the yeast Luc7p subunit of the U1 snRNP splicing complex that is normally required for 5-prime splice site selection (Tufarelli et al., 2001 [PubMed 11170747]).[supplied by OMIM, Mar 2008]
Transcription factors with Perturb-seq knockdown data for LUC7L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LUC7L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LUC7L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:52,954–54,208 | 175.7 kb | Distal (>10kb) Multiome | 950 | |
| chr16:71,378–73,062 | 157.9 kb | Distal (>10kb) Multiome | 639 | |
| chr16:77,240–78,636 | 151.3 kb | Distal (>10kb) Multiome | 685 | |
| chr16:138,551–139,186 | 90.8 kb | Distal (>10kb) Multiome | 674 | |
| chr16:164,983–166,147 | 64.4 kb | Distal (>10kb) Multiome | 234 | |
| chr16:180,313–181,713 | 47.9 kb | Distal (>10kb) Multiome | 994 | |
| chr16:228,869–229,598 | 143 bp | At TSS Multiome | 1035 | |
| chr16:234,152–235,669 | 5.4 kb | Proximal (<10kb) Multiome | 908 | |
| chr16:351,804–354,436 | 123.5 kb | Distal (>10kb) Multiome | 654 | |
| chr16:378,999–379,813 | 149.9 kb | Distal (>10kb) Multiome | 225 | |
| chr16:380,836–382,614 | 152.5 kb | Distal (>10kb) Multiome | 634 | |
| chr16:383,438–384,218 | 154.4 kb | Distal (>10kb) Multiome | 342 | |
| chr16:396,893–397,640 | 168.0 kb | Distal (>10kb) Multiome | 496 | |
| chr16:401,380–402,199 | 172.4 kb | Distal (>10kb) Multiome | 818 | |
| chr16:424,888–426,136 | 196.1 kb | Distal (>10kb) Multiome | 752 | |
| chr16:483,333–484,000 | 254.3 kb | Distal (>10kb) Multiome | 143 | |
| chr16:526,749–528,601 | 298.1 kb | Distal (>10kb) Multiome | 811 |
Genomic view of the LUC7L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.