Like most RING finger proteins, LTN1 functions as an E3 ubiquitin ligase (Chu et al., 2009 [PubMed 19196968]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for LTN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LTN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LTN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:28,884,897–28,885,668 | 107.6 kb | Distal (>10kb) Multiome | 1089 | |
| chr21:28,922,250–28,923,423 | 70.3 kb | Distal (>10kb) Multiome | 112 | |
| chr21:28,992,126–28,993,365 | 64 bp | At TSS Multiome | 927 | |
| chr21:29,002,426–29,003,155 | 9.9 kb | Proximal (<10kb) Multiome | 924 | |
| chr21:29,018,921–29,019,505 | 26.4 kb | Distal (>10kb) Multiome | 771 | |
| chr21:29,024,275–29,025,379 | 31.9 kb | Distal (>10kb) Multiome | 850 | |
| chr21:29,072,977–29,074,186 | 80.9 kb | Distal (>10kb) Multiome | 1002 |
Genomic view of the LTN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.