The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LTC4S. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LTC4S upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LTC4S, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:179,530,398–179,530,934 | 264.9 kb | Distal (>10kb) Multiome | 322 | |
| chr5:179,549,624–179,551,424 | 244.8 kb | Distal (>10kb) Multiome | 799 | |
| chr5:179,559,012–179,560,188 | 235.9 kb | Distal (>10kb) Multiome | 624 | |
| chr5:179,622,406–179,625,135 | 172.8 kb | Distal (>10kb) Multiome | 1217 | |
| chr5:179,678,118–179,679,585 | 117.0 kb | Distal (>10kb) Multiome | 1007 | |
| chr5:179,698,113–179,699,498 | 96.8 kb | Distal (>10kb) Multiome | 1062 | |
| chr5:179,732,076–179,733,697 | 62.8 kb | Distal (>10kb) Multiome | 820 | |
| chr5:179,795,059–179,796,988 | 665 bp | At TSS Multiome | 778 | |
| chr5:179,801,868–179,802,100 | 6.3 kb | Proximal (<10kb) | 257 | |
| chr5:179,805,642–179,807,610 | 11.4 kb | Distal (>10kb) Multiome | 747 | |
| chr5:179,818,809–179,822,095 | 25.3 kb | Distal (>10kb) Multiome | 1243 | |
| chr5:179,858,283–179,859,465 | 63.3 kb | Distal (>10kb) Multiome | 923 | |
| chr5:179,907,372–179,908,268 | 112.4 kb | Distal (>10kb) Multiome | 528 | |
| chr5:180,007,647–180,008,169 | 212.3 kb | Distal (>10kb) Multiome | 251 | |
| chr5:180,059,605–180,060,144 | 264.2 kb | Distal (>10kb) Multiome | 18 | |
| chr5:180,069,680–180,070,372 | 274.4 kb | Distal (>10kb) Multiome | 240 | |
| chr5:180,071,104–180,072,473 | 276.4 kb | Distal (>10kb) Multiome | 1084 | |
| chr5:180,090,117–180,091,054 | 294.9 kb | Distal (>10kb) Multiome | 575 |
Genomic view of the LTC4S locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.