Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for LSM6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSM6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSM6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:145,179,427–145,181,239 | 995.0 kb | Distal (>10kb) Multiome HiCAR | 855 | |
| chr4:145,887,216–145,887,983 | 288.2 kb | Distal (>10kb) Multiome | 199 | |
| chr4:145,909,209–145,909,939 | 266.2 kb | Distal (>10kb) Multiome | 176 | |
| chr4:145,935,719–145,938,595 | 239.8 kb | Distal (>10kb) Multiome | 694 | |
| chr4:145,938,677–145,939,163 | 236.8 kb | Distal (>10kb) Multiome | 664 | |
| chr4:146,175,371–146,176,493 | 137 bp | At TSS Multiome | 738 | |
| chr4:146,179,702–146,180,446 | 4.0 kb | Proximal (<10kb) | 126 | |
| chr4:146,182,539–146,182,779 | 6.8 kb | Proximal (<10kb) | 28 | |
| chr4:146,243,313–146,244,097 | 68.0 kb | Distal (>10kb) Multiome | 248 |
Genomic view of the LSM6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.