Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for LSM5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSM5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSM5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:30,983,471–30,984,223 | 1506.6 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr7:31,079,274–31,080,810 | 1410.2 kb | Distal (>10kb) Multiome HiCAR | 88 | |
| chr7:32,298,186–32,299,448 | 191.4 kb | Distal (>10kb) Multiome | 235 | |
| chr7:32,427,513–32,428,882 | 62.4 kb | Distal (>10kb) Multiome | 675 | |
| chr7:32,489,909–32,490,578 | 20 bp | At TSS Multiome | 997 | |
| chr7:32,494,947–32,496,378 | 5.1 kb | Proximal (<10kb) Multiome | 947 | |
| chr7:32,727,939–32,729,028 | 238.3 kb | Distal (>10kb) Multiome | 401 |
Genomic view of the LSM5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.