Enables RNA binding activity. Predicted to be involved in several processes, including maternal mRNA clearance; meiotic cell cycle process involved in oocyte maturation; and ovarian follicle development. Predicted to be located in cytoplasmic ribonucleoprotein granule. Predicted to be part of ribonucleoprotein complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LSM14B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LSM14B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LSM14B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:62,065,357–62,067,442 | 56.4 kb | Distal (>10kb) Multiome | 841 | |
| chr20:62,121,331–62,123,419 | 242 bp | At TSS Multiome | 961 | |
| chr20:62,142,789–62,144,593 | 21.1 kb | Distal (>10kb) Multiome | 841 | |
| chr20:62,182,546–62,183,326 | 60.5 kb | Distal (>10kb) Multiome | 1075 | |
| chr20:62,219,369–62,220,936 | 97.9 kb | Distal (>10kb) Multiome | 599 | |
| chr20:62,237,918–62,239,210 | 115.9 kb | Distal (>10kb) Multiome | 794 | |
| chr20:62,301,857–62,303,576 | 179.7 kb | Distal (>10kb) Multiome | 1110 | |
| chr20:62,365,805–62,369,404 | 246.6 kb | Distal (>10kb) Multiome | 960 | |
| chr20:62,386,553–62,387,309 | 264.5 kb | Distal (>10kb) Multiome | 885 | |
| chr20:62,406,793–62,407,817 | 284.9 kb | Distal (>10kb) Multiome | 935 |
Genomic view of the LSM14B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.