This gene encodes a ring finger protein involved in a variety of functions, including regulation of signaling pathways and cell adhesion, mediation of self-ubiquitylation, and involvement in cargo sorting during receptor endocytosis. Mutations in this gene have been associated with Charcot-Marie-Tooth disease. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jan 2012]
Transcription factors with Perturb-seq knockdown data for LRSAM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRSAM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRSAM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,199,063–127,199,676 | 252.2 kb | Distal (>10kb) Multiome | 315 | |
| chr9:127,223,725–127,226,151 | 226.7 kb | Distal (>10kb) Multiome | 713 | |
| chr9:127,244,905–127,245,629 | 206.2 kb | Distal (>10kb) Multiome | 447 | |
| chr9:127,396,281–127,398,388 | 54.5 kb | Distal (>10kb) Multiome | 843 | |
| chr9:127,423,809–127,424,734 | 27.2 kb | Distal (>10kb) Multiome | 791 | |
| chr9:127,450,607–127,452,473 | 90 bp | At TSS Multiome | 1009 | |
| chr9:127,567,936–127,569,972 | 117.7 kb | Distal (>10kb) Multiome | 660 | |
| chr9:127,608,129–127,608,913 | 157.0 kb | Distal (>10kb) Multiome | 700 | |
| chr9:127,611,734–127,612,761 | 160.7 kb | Distal (>10kb) Multiome | 566 | |
| chr9:127,699,155–127,699,632 | 247.9 kb | Distal (>10kb) Multiome | 440 | |
| chr9:127,715,013–127,716,345 | 264.3 kb | Distal (>10kb) Multiome | 735 | |
| chr9:127,734,444–127,735,606 | 283.8 kb | Distal (>10kb) Multiome | 836 | |
| chr9:127,741,739–127,743,092 | 291.3 kb | Distal (>10kb) Multiome | 367 |
Genomic view of the LRSAM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.