Predicted to be involved in long-term memory. Predicted to act upstream of or within visual learning. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRN4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRN4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRN4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:6,044,157–6,044,390 | 9.7 kb | Proximal (<10kb) | 77 | |
| chr20:6,051,939–6,053,048 | 1.0 kb | Proximal (<10kb) | 308 | |
| chr20:6,053,747–6,054,967 | at TSS | At TSS | 261 | |
| chr20:6,055,201–6,055,703 | 1.1 kb | Proximal (<10kb) | 144 | |
| chr20:6,058,492–6,059,323 | 4.4 kb | Proximal (<10kb) | 284 |
Genomic view of the LRRN4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.