The protein encoded by this gene belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. The encoded protein has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LRRN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:204,411,136–204,412,704 | 273.4 kb | Distal (>10kb) Multiome | 939 | |
| chr1:204,417,015–204,417,887 | 267.8 kb | Distal (>10kb) Multiome | 590 | |
| chr1:204,446,280–204,446,835 | 238.9 kb | Distal (>10kb) Multiome | 311 | |
| chr1:204,493,614–204,495,352 | 190.6 kb | Distal (>10kb) Multiome | 876 | |
| chr1:204,506,146–204,507,240 | 178.8 kb | Distal (>10kb) Multiome | 889 | |
| chr1:204,507,371–204,508,288 | 177.3 kb | Distal (>10kb) Multiome | 508 | |
| chr1:204,515,995–204,516,830 | 169.0 kb | Distal (>10kb) Multiome | 1084 | |
| chr1:204,565,653–204,566,244 | 119.4 kb | Distal (>10kb) Multiome | 403 | |
| chr1:204,684,550–204,685,936 | 121 bp | At TSS Multiome | 313 | |
| chr1:204,692,844–204,693,029 | 7.5 kb | Proximal (<10kb) | 184 | |
| chr1:204,714,466–204,715,865 | 29.7 kb | Distal (>10kb) Multiome | 356 | |
| chr1:204,806,979–204,807,672 | 121.9 kb | Distal (>10kb) Multiome | 641 | |
| chr1:204,828,302–204,828,945 | 143.3 kb | Distal (>10kb) Multiome | 287 | |
| chr1:204,923,251–204,924,645 | 239.0 kb | Distal (>10kb) Multiome | 297 | |
| chr1:204,927,214–204,930,121 | 243.9 kb | Distal (>10kb) Multiome | 387 |
Genomic view of the LRRN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.