Enables volume-sensitive anion channel activity. Involved in several processes, including monoatomic anion transmembrane transport; organic acid transmembrane transport; and protein hexamerization. Located in cytoplasm and plasma membrane. Part of monoatomic ion channel complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC8D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC8D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC8D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:89,523,795–89,525,737 | 296.2 kb | Distal (>10kb) Multiome | 1043 | |
| chr1:89,566,460–89,567,172 | 254.1 kb | Distal (>10kb) Multiome | 210 | |
| chr1:89,632,202–89,634,220 | 188.0 kb | Distal (>10kb) Multiome | 718 | |
| chr1:89,762,558–89,763,791 | 57.9 kb | Distal (>10kb) Multiome | 638 | |
| chr1:89,820,446–89,822,391 | 37 bp | At TSS Multiome | 889 | |
| chr1:89,842,655–89,844,211 | 22.5 kb | Distal (>10kb) Multiome | 610 | |
| chr1:89,910,443–89,911,186 | 90.0 kb | Distal (>10kb) Multiome | 247 | |
| chr1:89,994,463–89,995,789 | 174.1 kb | Distal (>10kb) Multiome HiCAR | 1039 |
Genomic view of the LRRC8D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.