Transcription factors with Perturb-seq knockdown data for LRRC75B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC75B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC75B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:24,423,554–24,424,614 | 169.2 kb | Distal (>10kb) Multiome | 450 | |
| chr22:24,554,481–24,556,186 | 37.7 kb | Distal (>10kb) Multiome | 1058 | |
| chr22:24,592,399–24,593,422 | 25 bp | At TSS Multiome | 650 | |
| chr22:24,805,933–24,806,542 | 213.1 kb | Distal (>10kb) Multiome | 489 |
Genomic view of the LRRC75B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.