Predicted to enable alpha-tubulin binding activity and dynein heavy chain binding activity. Predicted to be involved in outer dynein arm assembly. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRRC61. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC61 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC61, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:150,323,099–150,323,707 | at TSS | At TSS | 889 | |
| chr7:150,329,815–150,330,005 | 6.5 kb | Proximal (<10kb) | 96 | |
| chr7:150,340,210–150,341,978 | 18.4 kb | Distal (>10kb) Multiome | 416 | |
| chr7:150,368,010–150,369,898 | 45.3 kb | Distal (>10kb) Multiome | 1082 | |
| chr7:150,378,105–150,380,206 | 54.9 kb | Distal (>10kb) Multiome | 966 | |
| chr7:150,383,391–150,384,626 | 60.6 kb | Distal (>10kb) Multiome | 537 | |
| chr7:150,401,607–150,402,937 | 78.8 kb | Distal (>10kb) Multiome | 307 | |
| chr7:150,404,616–150,406,417 | 82.1 kb | Distal (>10kb) Multiome | 952 |
Genomic view of the LRRC61 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.