Predicted to be involved in modulation of chemical synaptic transmission and synapse organization. Predicted to act upstream of or within synapse organization. Predicted to be located in dendritic spine; excitatory synapse; and postsynaptic membrane. Predicted to be active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for LRRC4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:127,650,994–127,652,678 | 380.2 kb | Distal (>10kb) Multiome HiCAR | 1039 | |
| chr7:128,030,162–128,033,072 | 402 bp | At TSS Multiome | 422 | |
| chr7:128,035,815–128,035,993 | 4.8 kb | Proximal (<10kb) | 53 | |
| chr7:128,135,262–128,136,731 | 103.8 kb | Distal (>10kb) Multiome | 652 | |
| chr7:128,166,496–128,169,100 | 136.6 kb | Distal (>10kb) Multiome | 559 | |
| chr7:128,200,949–128,201,858 | 169.3 kb | Distal (>10kb) Multiome HiCAR | 168 | |
| chr7:128,266,969–128,267,714 | 235.3 kb | Distal (>10kb) Multiome | 395 | |
| chr7:128,298,870–128,299,537 | 267.2 kb | Distal (>10kb) Multiome | 53 |
Genomic view of the LRRC4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.