LRRC14

leucine rich repeat containing 14 | KIAA0014, LRRC14A

This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]

Biological processes 9 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)kinase binding (GO:0019900)kinase binding (GO:0019900)negative regulation of toll-like receptor signaling pathway (GO:0034122)negative regulation of toll-like receptor signaling pathway (GO:0034122)protein binding (GO:0005515)

Expression (TPM)

TFs regulating LRRC14 0 TFs

Transcription factors with Perturb-seq knockdown data for LRRC14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRRC14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LRRC14

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRRC14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr8:144,266,293–144,267,098	256.1 kb	Distal (>10kb) Multiome	162
chr8:144,290,981–144,292,410	231.1 kb	Distal (>10kb) Multiome	716
chr8:144,315,833–144,316,450	206.4 kb	Distal (>10kb) Multiome	396
chr8:144,325,768–144,327,719	195.7 kb	Distal (>10kb) Multiome	1016
chr8:144,331,281–144,333,847	190.6 kb	Distal (>10kb) Multiome	406
chr8:144,336,102–144,339,119	185.7 kb	Distal (>10kb) Multiome	922
chr8:144,353,907–144,355,227	168.0 kb	Distal (>10kb) Multiome	280
chr8:144,358,142–144,359,070	164.0 kb	Distal (>10kb) Multiome	719
chr8:144,369,349–144,369,916	152.9 kb	Distal (>10kb) Multiome	204
chr8:144,372,497–144,372,883	149.9 kb	Distal (>10kb) Multiome	160
chr8:144,372,993–144,375,084	148.6 kb	Distal (>10kb) Multiome	903
chr8:144,408,968–144,410,189	113.1 kb	Distal (>10kb) Multiome	920
chr8:144,427,691–144,429,571	94.0 kb	Distal (>10kb) Multiome	1000
chr8:144,443,691–144,445,047	78.2 kb	Distal (>10kb) Multiome	743
chr8:144,462,568–144,463,422	59.7 kb	Distal (>10kb) Multiome	548
chr8:144,463,885–144,468,178	56.8 kb	Distal (>10kb) Multiome	910
chr8:144,471,960–144,474,391	50.0 kb	Distal (>10kb) Multiome HiCAR	482
chr8:144,474,517–144,476,543	46.7 kb	Distal (>10kb) Multiome HiCAR	321
chr8:144,477,277–144,478,749	44.6 kb	Distal (>10kb) Multiome HiCAR	679
chr8:144,478,851–144,479,509	43.3 kb	Distal (>10kb) Multiome HiCAR	392
chr8:144,483,979–144,484,843	38.2 kb	Distal (>10kb) Multiome	125
chr8:144,495,748–144,496,431	26.5 kb	Distal (>10kb) Multiome	131
chr8:144,500,182–144,501,505	21.6 kb	Distal (>10kb) Multiome	484
chr8:144,507,995–144,510,268	13.7 kb	Distal (>10kb) Multiome	1067
chr8:144,517,168–144,518,442	4.7 kb	Proximal (<10kb) Multiome	637
chr8:144,521,935–144,523,450	64 bp	At TSS Multiome	663
chr8:144,524,105–144,525,099	2.1 kb	Proximal (<10kb) Multiome	264
chr8:144,526,399–144,529,305	4.5 kb	Proximal (<10kb) Multiome	934
chr8:144,529,455–144,530,630	7.6 kb	Proximal (<10kb) Multiome	284
chr8:144,580,290–144,581,657	58.2 kb	Distal (>10kb) Multiome	271
chr8:144,672,507–144,672,989	150.3 kb	Distal (>10kb) Multiome	150
chr8:144,684,108–144,686,340	161.8 kb	Distal (>10kb) Multiome	862
chr8:144,755,078–144,755,956	233.0 kb	Distal (>10kb) Multiome HiCAR	769
chr8:144,785,987–144,788,592	264.6 kb	Distal (>10kb) Multiome HiCAR	997
chr8:144,791,751–144,793,221	269.9 kb	Distal (>10kb) Multiome HiCAR	899
chr8:144,798,389–144,799,501	276.3 kb	Distal (>10kb) Multiome HiCAR	832

Genome Browser

Genomic view of the LRRC14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.