The protein encoded by this gene contains a leucine-rich repeat (LRR). It specifically interacts with TNFRSF9/4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily. Overexpression of this gene suppresses the activation of NF-kappa B induced by TNFRSF9 or TNF receptor-associated factor 2 (TRAF2), which suggests that this protein is a negative regulator of TNFRSF9-mediated signaling cascades. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for LRR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:49,366,267–49,367,349 | 232.2 kb | Distal (>10kb) Multiome | 117 | |
| chr14:49,585,877–49,587,282 | 12.4 kb | Distal (>10kb) Multiome | 966 | |
| chr14:49,598,179–49,599,418 | 98 bp | At TSS Multiome | 967 | |
| chr14:49,599,718–49,600,251 | 779 bp | At TSS | 49 | |
| chr14:49,620,144–49,621,897 | 21.8 kb | Distal (>10kb) Multiome | 930 | |
| chr14:49,633,485–49,635,896 | 35.4 kb | Distal (>10kb) Multiome | 1040 | |
| chr14:49,687,569–49,688,718 | 89.3 kb | Distal (>10kb) Multiome | 843 | |
| chr14:49,692,914–49,693,633 | 94.4 kb | Distal (>10kb) Multiome | 764 | |
| chr14:49,767,430–49,769,102 | 169.1 kb | Distal (>10kb) Multiome | 899 | |
| chr14:49,852,270–49,853,410 | 253.9 kb | Distal (>10kb) Multiome | 813 | |
| chr14:49,853,662–49,854,089 | 255.0 kb | Distal (>10kb) Multiome | 439 | |
| chr14:49,861,592–49,863,464 | 264.0 kb | Distal (>10kb) Multiome | 1038 | |
| chr14:49,867,745–49,868,682 | 269.3 kb | Distal (>10kb) Multiome | 699 | |
| chr14:49,892,363–49,894,019 | 294.0 kb | Distal (>10kb) Multiome | 981 |
Genomic view of the LRR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.