Enables phosphoprotein binding activity. Predicted to be involved in several processes, including response to cold; response to heat; and response to water deprivation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LRP11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRP11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRP11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:149,565,581–149,567,238 | 297.8 kb | Distal (>10kb) Multiome | 1021 | |
| chr6:149,648,112–149,649,264 | 215.3 kb | Distal (>10kb) Multiome | 1051 | |
| chr6:149,717,353–149,718,457 | 146.1 kb | Distal (>10kb) Multiome | 1074 | |
| chr6:149,746,178–149,746,876 | 117.5 kb | Distal (>10kb) Multiome | 812 | |
| chr6:149,749,354–149,750,638 | 114.3 kb | Distal (>10kb) Multiome | 967 | |
| chr6:149,863,201–149,865,192 | 309 bp | At TSS Multiome | 906 | |
| chr6:149,922,648–149,923,559 | 59.1 kb | Distal (>10kb) Multiome HiCAR | 419 | |
| chr6:149,925,530–149,926,657 | 62.2 kb | Distal (>10kb) Multiome HiCAR | 390 | |
| chr6:149,941,434–149,942,626 | 77.9 kb | Distal (>10kb) Multiome | 476 | |
| chr6:149,963,109–149,964,540 | 99.9 kb | Distal (>10kb) Multiome | 691 | |
| chr6:150,004,529–150,006,027 | 141.3 kb | Distal (>10kb) Multiome | 798 | |
| chr6:150,068,383–150,069,891 | 205.2 kb | Distal (>10kb) Multiome | 507 | |
| chr6:150,080,522–150,080,995 | 216.9 kb | Distal (>10kb) Multiome | 267 | |
| chr6:150,142,478–150,144,128 | 279.0 kb | Distal (>10kb) Multiome | 475 |
Genomic view of the LRP11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.