This gene encodes a leucine-rich repeat protein. The encoded protein is thought to play a role in melanocyte differentiation. Mutations in this gene have been associated with autosomal recessive oculocutaneous albinism 7 (OCA7). Alternatively spliced transcript variants have been identified. [provided by RefSeq, Mar 2015]
Transcription factors with Perturb-seq knockdown data for LRMDA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRMDA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRMDA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:75,188,012–75,188,453 | 243.4 kb | Distal (>10kb) Multiome | 268 | |
| chr10:75,206,644–75,207,978 | 224.2 kb | Distal (>10kb) Multiome | 207 | |
| chr10:75,209,910–75,211,260 | 221.0 kb | Distal (>10kb) Multiome | 1059 | |
| chr10:75,233,116–75,236,429 | 195.6 kb | Distal (>10kb) Multiome | 1015 | |
| chr10:75,294,540–75,295,659 | 136.5 kb | Distal (>10kb) Multiome | 702 | |
| chr10:75,395,145–75,397,482 | 34.4 kb | Distal (>10kb) Multiome | 341 | |
| chr10:75,398,678–75,400,431 | 31.7 kb | Distal (>10kb) Multiome | 501 | |
| chr10:75,400,704–75,404,045 | 29.5 kb | Distal (>10kb) Multiome | 978 | |
| chr10:75,404,151–75,405,735 | 26.5 kb | Distal (>10kb) Multiome | 760 | |
| chr10:75,408,986–75,410,039 | 22.2 kb | Distal (>10kb) Multiome | 639 | |
| chr10:75,417,113–75,418,105 | 13.8 kb | Distal (>10kb) Multiome | 296 | |
| chr10:75,430,070–75,430,739 | 883 bp | At TSS | 509 | |
| chr10:75,431,260–75,431,908 | at TSS | At TSS | 468 | |
| chr10:76,082,740–76,083,483 | 651.6 kb | Distal (>10kb) Multiome HiCAR | 259 |
Genomic view of the LRMDA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.