Transcription factors with Perturb-seq knockdown data for LRFN5-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRFN5-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRFN5-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:41,599,482–41,600,485 | 5.0 kb | Proximal (<10kb) Multiome | 121 | |
| chr14:41,600,617–41,600,999 | 4.0 kb | Proximal (<10kb) | 105 | |
| chr14:41,604,300–41,604,538 | 449 bp | At TSS | 31 | |
| chr14:41,604,704–41,607,844 | 335 bp | At TSS Multiome | 498 | |
| chr14:41,607,963–41,608,612 | 3.0 kb | Proximal (<10kb) | 156 | |
| chr14:41,609,471–41,610,541 | 4.5 kb | Proximal (<10kb) | 256 |
Genomic view of the LRFN5-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.