LRCH4

leucine rich repeats and calponin homology domain containing 4 | LRN, LRRN1

This gene encodes a protein that contains leucine-rich repeats (LRR) at its amino terminus and that is known to be involved in ligand binding. The carboxyl terminus may act as a membrane anchor. Identified structural elements suggest that the encoded protein resembles a receptor. [provided by RefSeq, Jul 2008]

Developmental clusters: GC6

Biological processes 10 terms

PML body (GO:0016605)PML body (GO:0016605)membrane raft assembly (GO:0001765)membrane raft assembly (GO:0001765)nervous system development (GO:0007399)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of toll-like receptor signaling pathway (GO:0034123)positive regulation of toll-like receptor signaling pathway (GO:0034123)protein binding (GO:0005515)

Expression (TPM)

TFs regulating LRCH4 0 TFs

Transcription factors with Perturb-seq knockdown data for LRCH4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRCH4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LRCH4

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRCH4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:100,335,652–100,336,470	250.0 kb	Distal (>10kb) Multiome	706
chr7:100,381,682–100,382,670	204.1 kb	Distal (>10kb) Multiome	49
chr7:100,428,059–100,431,175	157.2 kb	Distal (>10kb) Multiome	1296
chr7:100,435,379–100,436,927	149.6 kb	Distal (>10kb) Multiome	931
chr7:100,450,379–100,450,973	135.4 kb	Distal (>10kb) Multiome	785
chr7:100,478,582–100,479,753	106.7 kb	Distal (>10kb) Multiome HiCAR	842
chr7:100,482,937–100,484,533	102.5 kb	Distal (>10kb) Multiome	677
chr7:100,538,557–100,539,759	47.1 kb	Distal (>10kb) Multiome	858
chr7:100,542,221–100,542,986	43.4 kb	Distal (>10kb) Multiome	274
chr7:100,569,177–100,570,642	16.5 kb	Distal (>10kb) Multiome HiCAR	855
chr7:100,584,803–100,585,060	1.1 kb	Proximal (<10kb)	236
chr7:100,585,161–100,587,241	264 bp	At TSS Multiome	966
chr7:100,611,685–100,612,981	26.1 kb	Distal (>10kb) Multiome	767
chr7:100,626,427–100,627,057	40.6 kb	Distal (>10kb) Multiome	415
chr7:100,656,111–100,656,626	70.3 kb	Distal (>10kb) Multiome	653
chr7:100,673,043–100,674,892	87.4 kb	Distal (>10kb) Multiome	934
chr7:100,674,996–100,676,406	89.8 kb	Distal (>10kb) Multiome	439
chr7:100,691,570–100,692,163	105.7 kb	Distal (>10kb) Multiome	364
chr7:100,693,475–100,694,667	108.2 kb	Distal (>10kb) Multiome	607
chr7:100,705,140–100,706,426	119.8 kb	Distal (>10kb) Multiome	962
chr7:100,827,001–100,828,324	241.5 kb	Distal (>10kb) Multiome	794
chr7:100,835,906–100,837,766	250.7 kb	Distal (>10kb) Multiome	766
chr7:100,852,057–100,853,190	266.3 kb	Distal (>10kb) Multiome	805
chr7:100,874,652–100,875,664	288.9 kb	Distal (>10kb) Multiome	1020

Genome Browser

Genomic view of the LRCH4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.