This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for LRCH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LRCH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LRCH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:46,278,522–46,278,973 | 274.4 kb | Distal (>10kb) Multiome | 105 | |
| chr13:46,386,444–46,387,826 | 165.9 kb | Distal (>10kb) Multiome | 402 | |
| chr13:46,489,862–46,490,863 | 62.9 kb | Distal (>10kb) Multiome HiCAR | 168 | |
| chr13:46,551,351–46,551,459 | 1.7 kb | Proximal (<10kb) | 94 | |
| chr13:46,551,566–46,551,792 | 1.4 kb | Proximal (<10kb) | 281 | |
| chr13:46,552,427–46,554,523 | 57 bp | At TSS Multiome | 708 | |
| chr13:46,554,617–46,554,879 | 1.4 kb | Proximal (<10kb) | 394 | |
| chr13:46,796,424–46,797,697 | 244.0 kb | Distal (>10kb) Multiome | 930 |
Genomic view of the LRCH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.