The protein encoded by this gene is a member of the lipin family of proteins, and all family members share strong homology in their C-terminal region. This protein is thought to form hetero-oligomers with other lipin family members, while one family member, lipin 1, can also form homo-oligomers. This protein contains conserved motifs for phosphatidate phosphatase 1 (PAP1) activity as well as a domain that interacts with a transcriptional co-activator. Lipin complexes act in the cytoplasm to catalyze the dephosphorylation of phosphatidic acid to produce diacylglycerol, which is the precursor of both triglycerides and phospholipids. Lipin complexes are also thought to regulate gene expression as transcriptional co-activators in the nucleus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Transcription factors with Perturb-seq knockdown data for LPIN3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPIN3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPIN3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:41,135,300–41,135,808 | 205.4 kb | Distal (>10kb) Multiome | 451 | |
| chr20:41,136,345–41,138,443 | 203.6 kb | Distal (>10kb) Multiome | 1007 | |
| chr20:41,316,979–41,318,388 | 23.1 kb | Distal (>10kb) Multiome | 894 | |
| chr20:41,339,588–41,341,431 | 116 bp | At TSS Multiome | 904 | |
| chr20:41,365,890–41,367,375 | 26.0 kb | Distal (>10kb) Multiome | 273 | |
| chr20:41,617,502–41,619,268 | 277.8 kb | Distal (>10kb) Multiome | 758 |
Genomic view of the LPIN3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.