Mouse studies suggest that this gene functions during normal adipose tissue development and may play a role in human triglyceride metabolism. This gene represents a candidate gene for human lipodystrophy, characterized by loss of body fat, fatty liver, hypertriglyceridemia, and insulin resistance. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LPIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:2,894,188–2,895,797 | 118.1 kb | Distal (>10kb) Multiome | 326 | |
| chr18:2,906,043–2,907,458 | 106.2 kb | Distal (>10kb) Multiome | 675 | |
| chr18:3,012,394–3,013,832 | 170 bp | At TSS Multiome | 816 | |
| chr18:3,245,709–3,246,515 | 233.0 kb | Distal (>10kb) Multiome | 627 | |
| chr18:3,246,619–3,248,313 | 234.4 kb | Distal (>10kb) Multiome | 1018 | |
| chr18:3,261,342–3,262,799 | 248.9 kb | Distal (>10kb) Multiome | 929 | |
| chr18:3,296,788–3,297,724 | 284.3 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the LPIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.