This gene encodes a member of the lysophospholipid acyltransferase family. The encoded protein catalyzes the reacylation of lysophosphatidylglycerol to phosphatidylglycerol, a membrane phospholipid that is an important precursor for the synthesis of cardiolipin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Transcription factors with Perturb-seq knockdown data for LPGAT1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPGAT1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPGAT1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:211,577,546–211,580,066 | 251.3 kb | Distal (>10kb) Multiome | 1012 | |
| chr1:211,630,152–211,630,733 | 200.3 kb | Distal (>10kb) Multiome | 515 | |
| chr1:211,655,045–211,655,900 | 175.3 kb | Distal (>10kb) Multiome | 351 | |
| chr1:211,667,030–211,667,875 | 163.3 kb | Distal (>10kb) Multiome | 301 | |
| chr1:211,675,193–211,676,330 | 154.9 kb | Distal (>10kb) Multiome HiCAR | 936 | |
| chr1:211,695,364–211,695,890 | 135.0 kb | Distal (>10kb) Multiome HiCAR | 283 | |
| chr1:211,698,066–211,699,596 | 132.1 kb | Distal (>10kb) Multiome HiCAR | 651 | |
| chr1:211,829,389–211,829,579 | 1.1 kb | Proximal (<10kb) | 281 | |
| chr1:211,829,926–211,831,171 | 11 bp | At TSS Multiome | 682 | |
| chr1:211,889,249–211,890,017 | 58.9 kb | Distal (>10kb) Multiome | 139 | |
| chr1:211,895,246–211,895,795 | 64.8 kb | Distal (>10kb) Multiome | 267 | |
| chr1:212,034,569–212,036,407 | 204.7 kb | Distal (>10kb) Multiome | 995 |
Genomic view of the LPGAT1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.