The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]
Transcription factors with Perturb-seq knockdown data for LPAR6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPAR6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPAR6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:48,232,588–48,234,160 | 179.9 kb | Distal (>10kb) Multiome | 750 | |
| chr13:48,303,216–48,304,354 | 109.4 kb | Distal (>10kb) Multiome | 827 | |
| chr13:48,413,036–48,413,348 | at TSS | At TSS | 325 | |
| chr13:48,531,782–48,533,660 | 119.7 kb | Distal (>10kb) Multiome | 884 | |
| chr13:48,621,052–48,621,542 | 208.1 kb | Distal (>10kb) Multiome | 149 | |
| chr13:48,645,781–48,646,616 | 233.0 kb | Distal (>10kb) Multiome | 67 |
Genomic view of the LPAR6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.