LPAR2

lysophosphatidic acid receptor 2 | EDG-4, LPA2, EDG4

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

Biological processes 24 terms

G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor activity (GO:0004930)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)G protein-coupled receptor signaling pathway (GO:0007186)PDZ domain binding (GO:0030165)adenylate cyclase-activating G protein-coupled receptor signaling pathway (GO:0007189)cell surface (GO:0009986)cell surface (GO:0009986)cytoplasm (GO:0005737)endocytic vesicle (GO:0030139)glutamatergic synapse (GO:0098978)lipid binding (GO:0008289)lipid binding (GO:0008289)lysophosphatidic acid receptor activity (GO:0070915)membrane (GO:0016020)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of cytosolic calcium ion concentration (GO:0007204)positive regulation of cytosolic calcium ion concentration (GO:0007204)presynaptic active zone membrane (GO:0048787)protein binding (GO:0005515)

Expression (TPM)

TFs regulating LPAR2 0 TFs

Transcription factors with Perturb-seq knockdown data for LPAR2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPAR2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to LPAR2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPAR2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:19,384,944–19,386,424	242.6 kb	Distal (>10kb) Multiome	788
chr19:19,405,072–19,406,890	222.6 kb	Distal (>10kb) Multiome	1014
chr19:19,461,886–19,462,726	165.9 kb	Distal (>10kb) Multiome	345
chr19:19,515,735–19,516,510	112.0 kb	Distal (>10kb) Multiome	824
chr19:19,532,119–19,532,674	95.8 kb	Distal (>10kb) Multiome HiCAR	405
chr19:19,538,087–19,538,726	89.9 kb	Distal (>10kb) Multiome HiCAR	255
chr19:19,539,681–19,541,846	86.9 kb	Distal (>10kb) Multiome HiCAR	352
chr19:19,575,151–19,576,000	52.6 kb	Distal (>10kb) Multiome	128
chr19:19,618,285–19,619,315	9.4 kb	Proximal (<10kb) Multiome	414
chr19:19,627,596–19,629,138	227 bp	At TSS Multiome	543
chr19:19,637,337–19,638,344	9.4 kb	Proximal (<10kb) Multiome	153
chr19:19,643,155–19,644,142	15.5 kb	Distal (>10kb) Multiome	595
chr19:19,663,091–19,664,414	35.7 kb	Distal (>10kb) Multiome	848
chr19:19,668,196–19,669,404	40.5 kb	Distal (>10kb) Multiome	778
chr19:19,732,628–19,733,489	104.9 kb	Distal (>10kb) Multiome	701
chr19:19,775,960–19,777,126	148.3 kb	Distal (>10kb) Multiome	738
chr19:19,860,773–19,861,447	233.0 kb	Distal (>10kb) Multiome	112
chr19:19,865,643–19,866,347	237.6 kb	Distal (>10kb) Multiome	685
chr19:19,866,439–19,867,170	238.8 kb	Distal (>10kb) Multiome	306
chr19:19,900,670–19,901,891	272.7 kb	Distal (>10kb) Multiome	405

Genome Browser

Genomic view of the LPAR2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.