Apolipoprotein(a) is the distinguishing protein moiety of lipoprotein(a), of which elevated plasma levels are correlated with an increased risk of atherosclerosis. This gene is similar to the lipoprotein, Lp(a) gene, but all transcripts produced by this gene contain a truncated open reading frame and are candidates for nonsense-mediated decay. Consequently, this gene is considered to be a pseudogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]
Transcription factors with Perturb-seq knockdown data for LPAL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LPAL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LPAL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:160,226,067–160,227,928 | 293.1 kb | Distal (>10kb) Multiome | 133 | |
| chr6:160,239,954–160,240,660 | 279.6 kb | Distal (>10kb) Multiome | 51 | |
| chr6:160,347,395–160,349,344 | 172.2 kb | Distal (>10kb) Multiome | 674 | |
| chr6:160,519,691–160,521,033 | 97 bp | At TSS Multiome | 745 | |
| chr6:160,678,848–160,679,711 | 159.1 kb | Distal (>10kb) Multiome | 192 | |
| chr6:160,766,832–160,767,914 | 247.2 kb | Distal (>10kb) Multiome | 438 |
Genomic view of the LPAL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.