In human, peroxisomes function primarily to catalyze fatty acid beta-oxidation and, as a by-product, produce hydrogen peroxide and superoxide. The protein encoded by this gene is an ATP-dependent protease that likely plays a role in maintaining overall peroxisome homeostasis as well as proteolytically degrading peroxisomal proteins damaged by oxidation. The protein has an N-terminal Lon N substrate recognition domain, an ATPase domain, a proteolytic domain, and, in some isoforms, a C-terminal peroxisome targeting sequence. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for LONP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LONP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LONP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:46,972,819–46,974,091 | 1270.6 kb | Distal (>10kb) Multiome HiCAR | 975 | |
| chr16:48,050,630–48,051,441 | 193.2 kb | Distal (>10kb) Multiome | 61 | |
| chr16:48,117,171–48,117,887 | 126.7 kb | Distal (>10kb) Multiome | 334 | |
| chr16:48,244,113–48,244,792 | 56 bp | At TSS Multiome | 957 | |
| chr16:48,365,312–48,366,772 | 121.7 kb | Distal (>10kb) Multiome | 826 | |
| chr16:48,384,395–48,386,081 | 141.2 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the LONP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.