Predicted to enable ubiquitin-protein transferase activity. Predicted to act upstream of or within neural precursor cell proliferation and neuron differentiation. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LNX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LNX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LNX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:27,361,835–27,362,747 | 258.3 kb | Distal (>10kb) Multiome | 476 | |
| chr13:27,424,036–27,425,195 | 195.9 kb | Distal (>10kb) Multiome | 868 | |
| chr13:27,449,915–27,451,120 | 170.2 kb | Distal (>10kb) Multiome | 928 | |
| chr13:27,619,862–27,622,369 | 1.3 kb | Proximal (<10kb) Multiome | 1017 | |
| chr13:27,792,386–27,793,032 | 172.1 kb | Distal (>10kb) Multiome | 381 | |
| chr13:27,826,355–27,826,879 | 206.1 kb | Distal (>10kb) Multiome | 341 | |
| chr13:27,919,827–27,920,448 | 299.5 kb | Distal (>10kb) Multiome | 287 |
Genomic view of the LNX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.