Transcription factors with Perturb-seq knockdown data for LMNB1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LMNB1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LMNB1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:126,594,453–126,595,707 | 181.2 kb | Distal (>10kb) Multiome | 803 | |
| chr5:126,599,987–126,601,746 | 175.5 kb | Distal (>10kb) Multiome | 911 | |
| chr5:126,674,036–126,674,611 | 102.1 kb | Distal (>10kb) Multiome HiCAR | 99 | |
| chr5:126,718,055–126,718,948 | 58.0 kb | Distal (>10kb) Multiome | 184 | |
| chr5:126,735,879–126,736,525 | 40.2 kb | Distal (>10kb) Multiome | 84 | |
| chr5:126,776,292–126,778,844 | 437 bp | At TSS Multiome | 1113 | |
| chr5:126,779,927–126,780,507 | 3.4 kb | Proximal (<10kb) | 261 | |
| chr5:127,029,529–127,031,804 | 254.2 kb | Distal (>10kb) Multiome | 986 | |
| chr5:127,040,873–127,041,835 | 264.9 kb | Distal (>10kb) Multiome | 329 | |
| chr5:127,072,928–127,073,820 | 297.0 kb | Distal (>10kb) Multiome | 757 |
Genomic view of the LMNB1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.