Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within negative regulation of oligodendrocyte differentiation; negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and neuron development. Predicted to be located in plasma membrane. Predicted to be active in several cellular components, including extracellular space; glutamatergic synapse; and presynapse. Implicated in autosomal recessive intellectual developmental disorder 64 and glaucoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for LINGO1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINGO1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINGO1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:77,027,800–77,028,685 | 606.1 kb | Distal (>10kb) Multiome HiCAR | 156 | |
| chr15:77,419,234–77,421,343 | 214.1 kb | Distal (>10kb) Multiome | 941 | |
| chr15:77,496,731–77,497,500 | 137.3 kb | Distal (>10kb) Multiome | 517 | |
| chr15:77,510,024–77,510,883 | 123.9 kb | Distal (>10kb) Multiome | 121 | |
| chr15:77,543,155–77,543,857 | 90.8 kb | Distal (>10kb) Multiome | 680 | |
| chr15:77,604,253–77,604,752 | 29.8 kb | Distal (>10kb) Multiome | 145 | |
| chr15:77,630,922–77,631,706 | 3.0 kb | Proximal (<10kb) Multiome | 92 | |
| chr15:77,632,252–77,635,007 | 601 bp | At TSS Multiome | 831 | |
| chr15:77,818,998–77,820,547 | 184.8 kb | Distal (>10kb) Multiome HiCAR | 353 |
Genomic view of the LINGO1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.