Transcription factors with Perturb-seq knockdown data for LINC02937. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02937 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02937, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:91,036,858–91,037,648 | 70.6 kb | Distal (>10kb) Multiome | 720 | |
| chr9:91,061,677–91,062,488 | 45.9 kb | Distal (>10kb) Multiome | 90 | |
| chr9:91,193,714–91,194,128 | 85.8 kb | Distal (>10kb) Multiome | 920 | |
| chr9:91,361,213–91,362,454 | 253.9 kb | Distal (>10kb) Multiome | 745 |
Genomic view of the LINC02937 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.