Transcription factors with Perturb-seq knockdown data for LINC02882. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02882 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02882, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:74,285,653–74,286,633 | 6.3 kb | Proximal (<10kb) | 100 | |
| chr12:74,286,731–74,287,010 | 5.9 kb | Proximal (<10kb) | 4 | |
| chr12:74,292,350–74,293,196 | at TSS | At TSS | 333 | |
| chr12:74,293,517–74,293,995 | 573 bp | At TSS | 59 | |
| chr12:74,537,322–74,538,432 | 244.9 kb | Distal (>10kb) Multiome | 890 |
Genomic view of the LINC02882 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.