Transcription factors with Perturb-seq knockdown data for LINC02820. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LINC02820 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LINC02820, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:85,035,993–85,036,698 | 281.7 kb | Distal (>10kb) Multiome | 342 | |
| chr12:85,277,934–85,279,199 | 39.6 kb | Distal (>10kb) Multiome | 236 | |
| chr12:85,279,314–85,280,967 | 37.6 kb | Distal (>10kb) Multiome | 564 | |
| chr12:85,310,147–85,310,357 | 7.7 kb | Proximal (<10kb) | 37 | |
| chr12:85,317,654–85,318,480 | at TSS | At TSS | 102 | |
| chr12:85,374,864–85,375,484 | 57.1 kb | Distal (>10kb) Multiome | 128 | |
| chr12:85,468,371–85,470,210 | 151.4 kb | Distal (>10kb) Multiome | 484 |
Genomic view of the LINC02820 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.